AAYUSH KUMAR JHA, MEENAKSHI K. CHAUHAN
Objective : The primary objective of this study is to investigate the approaches for ophthalmic formulations which successfully can overcome the various anatomical and physiological barriers thus ensuring an enhancement in drug permeability and efficacy. The exploration also establishes role of in situ gels as an effective formulation concept to resolve the ongoing complications. Conclusion: The pharmacodynamic and pharmacokinetic studies under investigation showed an enhanced efficacy compared to conventional eye drops. Acetazolamide in situ formulation showed 2.29 fold more effective than Azopt, 2.37 fold more effective than cimdaex. In situ gel of timolol maleate was able to lower down the elevated IOP from 15.73 mm Hg – 17.73 mm Hg over course of 30 – 300 minutes and latanoprost in situ gel was effective for a sustained time interval of 72hr with compared to 24hr of Xalatan drop characterized by a decrease in IOP to the baseline.