1. Situs Slot KayaMendadak88
  2. Situs Slot Online Terbaik Dan Terpercaya No 1
  3. Slot Pragmatic Play
  4. Situs Slot Online Terpercaya
  5. Kumpulan Situs Judi Slot Terpercaya
  6. Game Slot Online
  7. Judi Slot Online Jackpot Terbesar
  8. Situs Judi Slot Online Terpercaya 2021
  9. Slot Joker123
  10. Agen Slot Online Resmi
  11. Slot Deposit Pulsa
  12. Daftar Situs Judi Slot Terbaik Dan Terpercaya No 1
  13. AloJudi Slot
  14. KayaMendadak88 Slot
  15. Situs Slot Gacor 2022
  16. Judi Slot Online Jackpot Terbesar Gampang Menang
  17. Joker123 Slot
  18. Daftar Situs Judi Slot Online Deposit Pulsa Terbaik
  19. Mesin slot gacor 88
  20. Mesin slot
  21. Link Slot Online
  22. Slot Via Dana
  23. situs judi slot terbaik dan terpercaya no 1
  24. Daftar Situs Bo Slot Online Gacor Terbaik 2022
  1. Slot Online
  2. Judi Slot Online Jackpot Terbesar
  3. Daftar Situs Judi Slot Online Terpercaya
  4. Judi Slot Terpercaya
  5. Kumpulan Situs Judi QQ Online Terpercaya
  6. Slot Online Terbaru
  7. Situs Game Slot Online Terbaik
  8. Daftar Situs Judi Slot Online Gacor Gampang Menang 2022
  9. Situs Slot Deposit Pulsa dan Slot Online Terbaik
  10. Slot Hacker
  11. Situs Slot Online Terbaik
  12. Slot Gacor Gampang Menang
  13. Situs Judi Slot Online Gacor Terbaik 2022
  14. Situs Judi Slot Online Jackpot Terbesar
  15. Slot Online Terpercaya
  16. Game Slot Penghasil Uang
  17. Situs Slot Online Terbaik 2021
  18. Situs Slot Online Terbaik dan Terpercaya
  19. Situs Slot Terbaik
  20. Situs Judi Slot Terbaik Dan Terpercaya No 1

Abstract

VALIDATION OF REPORTED HPLC METHOD FOR THE SIMULTANEOUSDETERMINATION OF ARTEMETHER AND LUMEFANTRINE IN LOW INCOME LABORATORIES

Author(s): MADUAGWU IFUNANYA JULIET, ONYEGBULE AHAMEFULE FELIX AND NGWOKE KENNETH GERALD

Objectives:Methods  used  in  drug  analysis  should  be  simple,  reproducible,  precise,  accurate  and  applicable  in  both  developed  and  underdeveloped  countries.  This  is exceptionally  important  in  Africa  where counterfeitsof lifesavingdrugs  abound.  It  is  therefore  necessary  that  independent  validation  of  published  new  analytical  methods should  be  carried  out  to  establish  reproducibility  and  suitability  in  low  income  countries.Methods: Two  sample  preparation  methods  and  one  high  pressure  liquid chromatography  (HPLC)  method  reported  for  the simultaneousdetermination  of  lumefantrineand  artemeter  in  Coartem®tablets  were  used  to  analyse  two  batches  of  30 Coartem®samples containing 24 tablets each. The analysis was carried out on a BLC-10 HPLC with a Dstar variable C18 (250 × 4.6mm, 5μm) column and UV detector (210 nm, 254 nm).The sample preparation methodsand HPLC conditions were as reported. Result:Quantitative determinations of the individual drug content in the samples were not possible because no linear correlation was obtained for the plot of area versus concentration of thereference standards.  Sample preparation methods are very important in  obtaining  good  chromatograms. Conclusion:The  methods  as  reported  in  those  published  work  may  not  be  effective  methods  for  the  simultaneous  determination  of artemether and lumefantrine in fixed dose combination tablets like Coartem® in low income laboratories.

Get the App