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Abstract

TO DESIGN MICROSPHERES OF THE ANTIBACTERIAL DRUG CEFACLOR AND OPTIMIZE ITS CHARACTERISTICS

Author(s): MANMOHAN SINGH JATAV, RAJU CHOUKSE, RAKESH PATEL

Aim: This study aims to design microspheres of the antibacterial drug Cefaclor and optimize its characteristics to improve the bioavailability as well as to reduce its side effects. This utilizes statistical software for the optimization of microsphere formulations for the drug Cefaclor. Method: Thirteen formulation were prepared and being evaluated. Out of the thirteen formulations the formulation F2 was found to be optimum. Therefore, formulation F2 was selected as an optimized formulation and entrapment efficiency, drug release for this formulation was carried out, and the drug content was found to be optimum in accordance with the official monograph. Result: The evaluations parameter of the F2 formulation, i.e. entrapment efficiency, % drug release 83.5%, 71.1% respectively result concluded that all the parameter with in acceptant range. Release kinetic that in-vitro drug release curve fitted under Zero order release, first order release. Out of which the zero order model show R2 value 0.962-0.990 is highest as compared to another model. The drug release was mainly by zero order.

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