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Abstract

THE VALUE OF PROCALCITONIN MEASUREMENT IN MENINGITIS PATIENTS

Author(s): SHAIMAA A. HAMEED*1, ZAINAB F. ASHOOR2, DUREED K. AL-SHAREEF

Background:Meningitis  is  defined  as  inflammation  of  the  membranes  that  surround  the  brain  and  spinal  cord  and  can  occur  at  any  age,  it  is  caused  by  infectious microorganisms include (bacteria, viruses, fungi, and parasites) and non infectious include (drugs, carcinoma and inflammatory disorder).                                              Objective:The objective of the present study was to evaluate the value of PCTlevels to discriminate between bacterial and non-bacterial meningitis patients.        

Methods:A  total  of  40  patients  with  meningitis  admitted  to  emergency  department  of  Baghdad  teaching  hospital  and  pediatrics  emergency  room  in  child  welfare  teaching hospital  were  followed  in  this  prospective  study.  Cerebrospinal  fluid  (CSF)  sample  where  collected  from  40  patients  and  serum  sample  collected  from  these  patients  and healthy person. NHSreal-time PCRtechnique using to identified the type of bacteria and serum levels of PCTwere measured.                    

   Results:The  diagnosis  of  meningitis  was  based  on  clinical  findings,  gram  staining,  culture,  and  chemical  analysis  of CSF.  Twenty-eight  of  patients  were  diagnosed  as bacterial meningitis and the other twelve patients as non-bacterial meningitis.The mean PCTlevel in patients with bacterial meningitis was 658.00 pg/ml, and the lower level was 21. Pg/ml, while the higher level in patients with non-bacterial meningitis was 11.00 pg/ml (mean level, 5.30 pg/ml). It is clear from the range of serum PCTlevel that there are no overlapping values seen for serum PCTin both groups. Conclusion:Serum PCTlevels can be used in the early diagnosis of bacterial meningitis and is more valuable marker than the other predictive marker. Similarly, they may be useful in differential diagnosis of bacterial and non-bacterial meningitis to assess treatment efficacy

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