Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): MOHAMMED A. DAKHIL, SHATHA M.J. AL-KHATEEB, ARSHAD F. RIDHA

Back ground: Acute coronary syndrome is a potentially life-threatening condition that affects millions of individuals each year. The introduction of biomarkers has brought improvement for both diagnostic and management of cardiac patients.Timely diagnosis of acute coronary syndrome in the emergency department remains challenging ,because of its delayed increase in plasma in the early phase of myocardial infarction , there is proof that copeptin is possibly useful as a diagnostic and prognostic biomarker in various cardiovascular diseases. Objective: This study carried out to evaluate serum copeptin levels in patients with acute coronary syndrome and healthy persons and study the correlation of these levels as indicator for patients with risk factors. Patients & Methods: A total (58) referred male patients with acute coronary syndrome were included in this study with age range (23-75year) and also included (30) healthy persons served as control with age range (27-70year). Random blood sugar ,lipid profile (total cholesterol, triglyceride, High density lipoprotein cholesterol and low- density lipoprotein cholesterol), troponin I, creatine kinase-MB and copeptin were measured for acute coronary syndrome patients and control . Results: Serum copeptin and lipid profile were significant increased in acute coronary syndrome in comparison with control group, while the level of high density lipoprotein decreased in sick patients in comparison with control group. Negatively significant correlation was found between Ejection Fraction and serum copeptin in acute coronary syndrome patients. Positively significant correlation was found between copeptin, troponin , creatine kinase -MB.