SHAKER MOHAMMED JASIM *1,HUSSEIN RAWAA ABDULKHALEQ
Background: Leptin, a 16-kDa protein secreted from white adipocytes, has been implicated inthe regulation of food intake, energy expenditure, and whole-body energy balance in humans, therefore may be a mediator of anorexia associated with acute and chronic inflammation. In all parasitic infections there is loss of appetite and anorexia. Objective:The aim of the present study is to analyze serum leptin concentration in children infected with intestinal parasites (Entamoeba histolytica\dispare and Giardia lamblia) and compare them with healthy controls. Patients and methods:A total of 70 males and females patients infected with intestinal parasites presentedto the Central Teaching Hospital for Pediatric in Baghdad city -Iraq, during the period from April toSeptember, 2013. The age of patients ranged from5 to 15 years. Thirty healthy parasite-free individuals consider to be a control group. Stool samples were collected from patients for direct microscopic examination, then body weight, height and body mass index (BMI) were measured for all patients and controls. Serum leptin concentrations were detected by immunoenzymometric assay using the DRG Company Leptin ELISA kit. Statistical analysis was made by Chi-Square test using SAS version 9.1. Results:In this study 70 Patients infected with intestinal parasites, 40patients confirmed to be positive for E. histolytica\dispare and 30 patients for G. lamblia. The results showed serum leptin levels were not statistically significant between patient: 2.234±0.13ng/ml and control: 2.171±0.23; p > 0.05, at the same time, highly differences noticed between two age groups of patients with concentration of leptin, related to that leptin levels are increased in aged parallelingchanges in fat mass. In addition, we found significant differences between age, weight and BMI with concentration of leptin. but the height of patients were not statistically significant with concentration of leptin.Conclusion:We need further investigations with the different parasites for analyze the role of leptin in parasitic infections.