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Abstract

STOMACH-SPECIFIC MUCOADHESIVE NANOPARTICLES AS A CONTROLLED RELEASE DRUG DELIVERY SYSTEM

Author(s): KHARIA ANKIT ANAND, SINGHAI AKHLESH KUMAR

In recent years scientific and technological advancement have been made in the rate controlled oral drug delivery system by overcoming physiological adversities, such as short gastric residence time (GRT) and unpredictable gastric emptying time (GET). So an interest increased towards novel dosage forms, that can retained in the stomach for a prolonged and predictable period of time. The concept of such novel dosage forms is to decrease the GI transit rate of the drug delivery system by attachment to the mucus layer, thereby increasing the overall time for drug absorption. A further advantage of such delivery systems is that the drugno longer must diffusethrough the luminal contents in order to reach the mucosal epithelium. Various polymers have been used in the formulation of stomach specific mucoadhesivenanoparticles for drug delivery to increase therapeutic  benefit,  while  minimizing  side  effects.  Herewe  have  discussed  about  concept  of  gastric  emptying,  absorption  window,  potential drug  candidates,  technological development  evaluation  and  applications  for  stomach-specific  mucoadhesive  nanoparticles.  Marketed  products  for  oral  nanoparticulate  drug  delivery  systems  are  also discussed in this review.

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