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Abstract

ROLE OF CALCIUM IONS IN AQUEOUS HUMOUR DYNAMICS AND POTENTIAL OF CALCIUM CHANNEL BLOCKERS AS OCULAR DRUG DELIVERY AGENTS IN THE MANAGEMENT OF GLAUCOMA

Author(s): DEV JAIN, MEENAKSHI K. CHAUHAN

Objective: Glaucoma, a progressive optic neuropathy, is the leading cause of irreversible blindness worldwide. Pharmacologic treatment for glaucoma is directed towards lowering intraocular pressure (IOP) to slow disease progression and delay visual field loss. The effect of calcium channel blockers on intraocular pressure and aqueous humor dynamics remains still controversial, although preliminary evidence suggests that these drugs may be beneficial in the management of ocular hypertension and low-tension glaucoma. There is evidence of the role of calcium ions in the physiology of aqueous humor. This study aims to systematically review and summarize the role of calcium ions in the secretion and dynamics of aqueous humor and the potential use of CCB’s as new pharmacologic options for the treatment of glaucoma. Conclusion: After a complete review of the action of calcium channel blockers on the physiology of aqueous humor dynamics we have found out the potential effect of these agents in Glaucoma and how calcium channel blockers can be utilized in the ocular therapy of Glaucoma.

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