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Abstract

RECENT ADVANCES INGASTRO RETENTIVE DRUG DELIVERY SYSTEM: A REVIEW

Author(s): MISHRA JHANSEE, DASHALOK KUMAR

Several  controlled  oral  drug  delivery  systems  with  prolonged  gastric  residence  time  have  been  reported  recently.  Gastro  retentive  drug  delivery  system  is  an  approach  toprolong gastric residence time, thereby targeting site-specific drug release in upper gastro intestinal tract improving the oral sustained delivery of drug that have an absorption window  in  a  particular  region  of  the  gastrointestinal  tract.  These  systems help  in  continuously  releasing  the  drug  before  it  reaches  the  absorption  window,  thus  ensuring optimal bioavailability.  Various  approaches  for  gastric  retention  are  Floating  system,  Swelling  and  expanding  system,  Bioadhesive  systems,  Modified-shape  systems,  High density systems etc.

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