Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): S. PRATHYUSHA1, Y. MOHAN KUMAR2, D. LAVANYA3, M. KIRAN KUMAR

The  present  study  is  performed  by  preparation  and  evaluation  of  floating  tablets  of  quetiapine fumigateas  model  drug  for  prolongation  of  gastric  residence  time.  Floating effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose HPMC ( K4M , K100M, KE15, PLAIN ) , Sodium CMC, PVPK 30, crospovidone, Ethylcellulose, MCC, PGMS, polymerswithexcipients sodiumbicarbonate ,citric acid, lactose, magnesium stearate and talc and evaluated for floating properties, hardness, friability, dissolution, tap density and in vitro drug release studies. The gastro-retentive delivery systems of Quetiapine fumarate weresuccessfully developed in the form of hydrodynamically balanced tabletstoimprovethelocalactionanditsbioavailability,whichreducesthe wastage of drug and ultimately improves thesolubility for drugs that are less solubleinhighpHenvironment thereby improving h, the patient compliance