Abstract

PHOSPHORIMIDATE DERIVATIVE OF ACYCLOVIR; ANTIVIRAL ACTIVITY AGAINST CANINE PARVOVIRUS IN VITRO

Author(s): PAYAL M. OAK, AKASH S. MALI, ATUL R. CHOPADE, VISHAL BODAKE, VIJAY N. RAJE

Canine parvovirus is a very transmissible, severe and often deadly infectious disease of dogs caused by Type II canine parvovirus (CPV-2). According to a recent report, acyclovir has been effective candidate against parvovirus infection, however, a continuous spread of CPV-2 infections is observed, even in shelters where an appropriate vaccination program is applied, and this is a reason to provide antiviral drug therapy. The aim of the present study was to the development of antiviral drugs with the determination of the effect of concentration of new chemical entities and analyze Acyclovir analogous against CPV-2 strains. A sensitive in vitro assay capable of measuring the infectivity of CPV-2 was employed to determine the efficacy of different concentrations of 9-(2-hydroxyethomethyl) guanine phosphoro-mono-morpholidate. We successfully show that new compound inhibits CPV-2 replication by exhibiting 50% inhibitory concentrations (IC50s) in the low micromolar range (50μM ).

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ISSN: 2320-3315

ICV :81.58