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Abstract

PHARMACOLOGY AND TOXICOLOGICAL ANALYSIS IN SILICO AND HEALING ACTIVITY IN VITRO OF FLAVONOID LUTEOLIN ISOLATED FROM PROSOPIS JULIFLORAT

Author(s): GIANI MARIA CAVALCANTE, JAQUELINE SILVA AMORIM, MARIANA PEREIRA DE SOUZA, ANDR

Introduction: the Flavonoids are benzo-γ-pyrone derivatives consisting of phenolic and pyrane rings, are present in plants and are synthesized by phenylpropanoid pathway. Luteolin (3',4',5,7-tetrahydroxyflavone) is a flavonoid exerts a variety of pharmacological activities including anti-oxidant properties. Objective: the aimed to analyze pharmacology and toxicological in silico and evaluate the in vitro wound healing potential of Luteolin. Methods: The in silico study were performed with the software Passonline, Molinspiration Cheminformatics and admetSAR. The in vitro study was using the spreading and migration capabilities of fibroblast cell line.Results and discussion:the luteolin isolated from Prosopis juliflora showed 25 possible pharmacological activities and adverse and toxic effects with genotoxic, nephrotoxic, neurotoxic. Was not classified as carcinogenic, and the acute oral toxicity. Conclusion: strach assay showed that the luteolin from P. juliflora allowed the cellular migration in 45% more than the control.

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