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Abstract

PAST AND FUTURE OF PHARMACOKINETIC AND PHARMACODYNAMIC STUDY OF HERBAL DRUGS

Author(s): MANISHA SAHU, RAJ KUMAR TIWARI, VIKAS SHARMA, SHIV SHANKAR SHUKLA, RAVINDRA KUMAR PANDEY

Aim: Plants are the most vital sources of medicines. Many people preferred plant based medicine for the improvement of their health conditions alone or in combination with others. In recent years, more and more Pharmacokinetic (PK) & Pharmacodynamic (PD) Parameters are applicable for investigation of active components in herbal medicine. Background: The PK parameters includes Bioavailability (Cmax, tmax, AUC), Absorption rate constant(Ka), Volume of distribution, Distribution equilibrium, Distribution rate constant, Clearance, Half–life, 1st order ,0 order & mixed order kinetics, Elimination rate constant(Kel, Ka, Km ) And PD parameters includes Drug- receptor binding, Drugdrug interaction. Few research studies reported that PK & PD parameters used for herbal drugs; such as Garlic, Ginger, Curcumin, Licorice, Vinca, Emblica officinalis, Schisandra chinensis, Rhizoma coptidis, Pueraria lobata, Herba Ephedrae, Nao-De-Sheng, Corydalis bungeana, Radix Aconiti Lateralis, Praeparata Rhubarb peony, SuanZao-Ren, Ginseng, Ginko, Green tea, Danshen, Ding quai, Kava, St John’s wort, Grapefruit juice, Nauclea latifolia, Echinacea purpurea and Tobacco. PK & PD study of herbal drug is mainly used for drug development, identifying drugs biological properties, determination of drug concentration in body, drug efficacy. Conclusion: This review discuss about the past and future PK and PD studies, benefits and future studies of herbal drugs and will be helpful for young researchers who are involved in the field of herbal plants and also provide commercialization of herbal products.

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