Abstract

INCIDENCE OF JAK2V617F MUTATION IN IRAQI PATIENTS WITH PHILADELPHIA POSITIVE CML

Author(s): Marwah Hasan Abd Ali AL-Kaabi1, Yusra Ghiath Yaseen Al-Obaidy1, Shahla ?a Fadhil Sabir1and Israa Mohamed Safi AL-Kadmy

Objective:The aim of this study was to detect the occurrence of JAK2 V617F mutationin CML Iraqi patients. Methods: In this study 89 blood samples were collected from Iraqi CML patients who receiving imatinib mesylate or nilotinib as a treatment at National Center of Hematology during the period January 2013-June 2013, then DNA were extracted and ARMS-PCR technique was performed to detect the JAK2V617f mutation. Results:Out of 89 patients, JAK2V617F mutation was detected in only one patient (1.1%), a  52  year-old  woman  who  was on  Imatinib  mesylate  therapy  for  five  years.  Conclusion: Such rare  patients  with  co-existingBCR-ABL  translocation and  JAK2V617F mutation must be identified in view of the possibility of targeted therapies

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ISSN: 2320-3315

ICV :81.58

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