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Abstract

HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITIES OFETHANOLIC ROOTS EXTRACT OF CROSSOPTERYX FEBRIFUGA IN ALLOXAN-INDUCED DIABETIC RATS

Author(s): A.O. OJEWALE 1*, O. T. OLANIYAN3, O.K YEMITAN2, O. A. ODUKANMI4, B. J. DARE5, W.S. NNAEMEKA6,O.OMOAGHE7, A.M. AKINGBADE1,O.S. OGUNMODEDE1and A.O. ADEBARI

Objective:The study investigated the activities of antihypoglycemic and antihypolipidemic of ethanolic roots extract of Crossopteryx febrifuga(CF)in alloxan-induced diabetic rats. Methods:Twenty male albino rats were randomly distributed to four groups; I, II, III and IV with each consisting of five animals received extracts as follows: Group I, C .febrifuga(500 mg/kg bwt); Group II, C.febrifuga (250 mg/kg bwt); Group III, C. febrifuga (100 mg/kg bwt); Group IV, 0.5 ml (2% w/v) acacia solution and served as control. After 30 min, the animals  were  each  administered  orally  with  20%  (w/v)  glucose  at  a  dose  of  0.5ml  /100  g  bwt.  Blood  glucose  levels  were  then  monitored  at  30,  60,  and  120  min.  intervals  and reported  as  the  average  glucose  level  of  each  group.  Twenty-Five  (25)  Albino  rats  were  randomly  divided  into  five  (5)  experimental  groups:  control,  diabetic,  standard  drug (glibenclamide) and C. febrifuga(375 and 500 mg/kg bwt)treated diabetic groups. The animals in four out of five groups were fasted for 18 h andwere made diabetic by injectingwith  a  single  dose  of  alloxan  (ALX)  150  mg/kg.  Blood  was  collected  on  days  0,  5,  10  and  15  for  glucose  estimation  and  day  15 for  lipid  profile  assay. Results: A  significant reduction  in postprandial sugar  level was  observed  after  60  min  in  all  treatments.  Alloxan-induced  diabetic  rats  without  treatment  showed  significant  increases  (  p  <  0.05)  in  the levels of blood glucose, triglycerides, total cholesterol, low density lipoprotein LDL-cholesterol while the high density lipoprotein HDL-cholesterol level were significantly decreased ( p< 0.05) compared to normal rats. In addition, the diabetic rats treated with the CF and glibenclamide showed significant decrease ( p< 0.05) in both  blood glucose, TG and LDL-cholesterol  levels  and  a  significant  decrease  (  p<  0.05)  in  HDL-cholesterol  level compared  to  diabetic  untreated  rats. Conclusion:  The ethanolic  roots extract of Crossopteryx febrifuga(CF) possesses potential hypoglycemic and hypolipidemic activitiesin alloxan-induced diabetic rats

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