NADUGOPALBHUYAN, J K KHUNTIA, DEEPAK KUMAR, C P MEHER
Objective: Now in the development of human civilization the ulceration is becoming a life threaten disease due to imbalance between acid pepsin secretion and mucosal defense factors by stress, strain in day to day life style modification. To full fill the great demand of medicine, the modern approach of science makes the modernization of therapy by means of allopathic system of medicine, in which most drugs having more side effects. At the same time, synthetic drugs are very costlier which is not afforded by the people of below the poverty. So, in this context our main objective is to detect anti-ulcer study by using herbal formulations. Materials and methods: we used two herbs i.e Aegle marmelos & Elephantopus scaber for CHURNA preparation.Here swis albino rats are used for detect the anti-ulcer study. 24 swis albino rats were divided into 4 groups and each group containing 6 rats.The anti-ulcer activity demonstrated by using two methods i.eAcid determination method & Ulcer index method. Results: In acid determination method, the group-I which contain formulated Churna, having an average range of 5.3 which is nearly comparable with the group-II,that contain highly significant Ranitidine.In ulcer index study, here also a good result of group-I having 2.58 score whereas group-II having a score of 1.6. Conclusion: From the results, it is apparent that our CHURNA preparation induced group having high protectivity as compared to our standard drug. So, CHURNA preparation for anti-ulcer study has therapeutic effect as much the synthetic drug and having negligible side effect.