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Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF CARVEDILOL USING CROSPOVIDONE

Author(s): CHINMAYA KESHARI SAHOO, ABHIGNYA VOJJALA, BUCHANPALLY VIKRAM REDDY, G. SANTHOSHINI REDDY

Objective: The objective of the study was to formulate fast dissolving tablets (FDT) of carvedilol. Methods: Wet granulation method was adopted for the development of FDT using super disintegrant crospovidone. Pre compression parameters, post compression parameters, wetting time, in vitro dispersion time, and in vitro dissolution study were evaluated for developed formulation. Compatibility studies of formulations were determined by Fourier Transform Infrared Spectroscopy (FTIR) Results: CP4 formulation showed maximum 91.67 % of drug release at the end of 40 minutes among all 4 formulations. Short term stability studies (at 40±2ºC/75±5% RH) were conducted on CP4 formulation showed that there no significant changes in physiochemical parameters, drug content, and in vitro dissolution study. From the FTIR study showed that there were no drug excipient interactions for developed formulation. Conclusion: It was observed that dissolution profile of carvedilol is more in CP4 batch as it contains more amount of crospovidone.

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