Mintage Journal of Pharmaceutical and Medical Sciences (ISSN: 2320-3315)

Author(s): MOHAMMED AZIZ1*, KAMAL OUBENCHIKER2, AHMED KARIM2, HASSANE MEKHFI1, MOHAMED BNOUHAM1

Objective:Diarrhea  has  long  been  recognized  as  one  of  the  most  important  health  problems  in  developing  countries.  This  study  aimed  at  investigating  the  antidiarrheal activity  of  aqueous  extract  obtained  from  the  aerial  parts  of Cistus  salviifolius  L.  (AqCS).Methods:The  AqCS  was  tested  for  antidiarrheal  activity  using  two  experimental animal models: Antidiarrheal test using castor oil and gastrointestinal motility using charcoal method.Results: Comparative evaluation of the extracts with the antisecretory and antimotilitydrug, loperamide hydrochloride, and distillate water showed that the extracts (300, 600 mg/kg, p.o.) dose-dependently and significantly delayed the onset of castor  oil-induced  diarrhea,  decreased  the  frequency  of  defecation  and  reduced  the  severity  of  diarrhea  in  the  rats.  Also  the  extract  significantly  inhibited  gastrointestinal motility  in  mice  in a  dose dependent manner.Conclusion:The  results  obtained showed  that  the AqCS  may  contain  some  biologically  active  principles  that may  be  active against diarrhea and this may be the basis for its use traditionally for gastrointestinal disorders