MOHAMAD REZA HAVASIAN, PARNIAN TAJBAKHSH, JAFAR PANAHI
Objective:Staphylococci aureus and Coagulase-negative staphylococci (CoNS) are a major source of infections associated with indwelling medical devices. Macrolide antimicrobial agents are widely used across the world to protect against bacterial infection. Methods:This is a systematic review study valuating all pubmed, science direct, Scopus and Google scholar articles about the Evaluation of macrolide resistance in Staphylococcus aureus between 2010 –2013 using analytical statistical analysis. Data were collected and the related information extracted and put in statistical package and analyzed. Results: According the result of this study prevalence of macrolide resistant in some of region was more than other region and it caused by different conditions. The most common genes in macrolide resistant was erm(A) but could not be found in regulatory region of the isolates. Conclusion: We should try to reduce the resistant to antimicrobial drug by set the healthy plane and reduce using of antimicrobial drug.