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Objective: Cisplatin, alkylating anti-cancer agent is most widely-used to treat cancers. Due to the various organ toxicities its use is limited. Current ongoing research has made us understand the detailed mechanisms of these toxicities. Some researchers studied the protective activity of phytoconstituents to mitigate these toxicities. Phytochemicals like Quercetin, Curcumin, Lycopene, Chrysin, Sinapic acid, etc have been studied for their protective activity against all these toxicities. In this review, importance of phytoconstituents and detailed mechanism of their protective activity against Cisplatin-induced toxicities are discussed.Conclusion- The main focus of this article is to provide broader knowledge regarding prevention of Cisplation induced toxicities and reduce the mortality rate. This can be achieved by adding combination of Phytochemicals and Cisplatin which can give synergistic and combination effects.

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