EFFECTS OF METHANOLIC EXTRACT OF CELERY SEEDS ON EPILEPSY IN MICE

ZENA HASAN SAHIB

Abstract

EFFECTS OF METHANOLIC EXTRACT OF CELERY SEEDS ON EPILEPSY IN MICE

Author(s): ZENA HASAN SAHIB

Background:Epilepsy is a neuropsychological disorder, characterized by recurrent spontaneous seizures. all current drugs used have synthetic origin that causes severe side effects. One major disadvantage of drugs acting via the benzodiazepine site of GABA receptors is their tolerance, dependence, and abuse tendency. Hence, search for antiepileptic;compounds ;with same effects and lower side effects. Celery seed has been found to help regulate nervous system by producing a calming effect.Objectives:activity of methanolic extract of celery (apium graveolens)seed (AGM) on seizure were studied using lidocaine to induce seizure in mice.Methods:the efficacy and interaction of the extract (200mg/kg) was compared with standard anticonvulsant drug the diazepam (1mg/kg). Results:The extract extremely significant delay the onset of ataxia, and latency of seizures (p<0.001) and decreased the duration of convulsion ( p<0.001) and providea non significant protection in 4 out of 7 mice with no change in the onset of drowsiness. The diazepam group also showed delay in the onset of ataxia (p<0.05), and latency of seizures (p<0.001) and decreased the duration of convulsion ( p<0.001) and provide protection in 5 out of 7 mice (p<0.01), while the onset of drowsiness were extremely significant decreased ( p<0.001). The combination of extract and diazepam showed extremely significant delay in the onset of ataxia, the onset of drowsiness were extremely significant decreased ( p<0.001), with full protection 7/7 of mice that experience the induced seizures with lidocaine in compare to control group.Conclusion:these findings suggest that the methanolic extract of apium graveolens seed has anticonvulsant properties, and potentiate the diazepam effects

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