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Objective: The aim of the present study was to evaluate the antimicrobial activity of crude extracts of Janiarubens against Vibrio parahemolyticus. Methods: The methanol, ethanol, chloroform and acetone extracts of the red alga Janiarubens were prepared by cold maceration method and their antimicrobial activity was determined by disc diffusion method. Basic phytochemical tests were used to screen the phytochemical constituents present in the extracts. Results: The extracts upon phytochemical screening showed the presence of alkaloids, triterpenoids, steroids, tannin, saponin, coumarins, terpenoids, quinine, phytosteroids, phlobatannins, and flavonoids. Among the four solvents tested, methanol and ethanol extracts of seaweeds exhibited the best activity. Conclusions: The red alga J. rubens has significant antimicrobial activities. Further studies must be carried out to identify the main active constituent (s) and its safety levels

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