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Abstract

ANTIFUNGAL ACTIVITY ASSOCIATED WITH Psoralea corylifolia Linn. (BAKUCHI) SEED AND CHEMICAL PROFILE CRUDE METHANOL SEED EXTRACT

Author(s): A. BORATE*, M. UDGIRE , A. KHAMBHAPATI

Objective:Present study aims to evaluate antifungal efficacy ofBakuchi (Psoralea corylifolia) seed extracts prepared in methanol solvents and the bakuchi oil. Bakuchi seed used in the formulations against skin related diseases and disorders in Ayurvedic system of medicine.Method:Antifungal assay was performed by agar well diffusion method against common fungal skin pathogens Candida albicans, Aspergillus niger and Malassezia furfur.Results:Bakuchi  seeds  extract  in  methanol  was  observed  the  most  promising  antifungal  activity  against  the  selected  skin  pathogens.  The  phytochemical  and  GC  MS analysis  confirmed  the  presence  of  several  bioactive  components  including  phenol  derivatives  as  coumarin–psoralen,  isopsoralen  which  might  be  accountable  for  its antifungal activity.

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